Albany State University Awards
- Project Name: Toward a Systematic, High-Throughput Screening of the Toxicity of Various Organophosphate Compound
Awarding Agency: Defense Threat Reduction Agency
Project Summary:
Organophosphate compounds (OPCs) are well known as chemical warfare nerve agents and as pesticides that present a great challenge to public safety. There is an urgent need for testing and characterizing biological responses including cytotoxic effects of each and every potentially hazardous organophosphate compounds (OPCs) that are available. The research project focuses on pesticides in this proposed study to characterize the cellular responses and to construct predictive models.
Outcome:
The project successfully assessed the toxic potential and cellular responses of organophosphates compounds--cell viability studies and the toxic potential and cellular responses of organophosphates compounds--gene expression responses upon organophosphate treatments, tested and evaluated the In silico approach to predictive toxicology of organophosphate compounds, and completed the development of a high-throughput screening (HTS) method for organophosphate compounds.
